王梓珊,博士,在复杂疾病领域的多组学数据整合分析方面具有丰富的经验,共发表SCI论文14篇,编写一章书籍,以第一(或共一)作者在Nucleic Acids Research, Genome Medicine, Briefings in Bioinformatics等国际学术杂志发表SCI论文5篇。
教育及培训经历:
2009.09-2014.07哈尔滨医科大学 生物信息科学与技术学院 生物信息学 学士
2014.09-2019.07哈尔滨医科大学 生物信息科学与技术学院 生物信息学 博士
2019.09-至今 纽约西奈山伊坎医学院 遗传学院 博士后
获奖情况:
本科期间:哈尔滨医科大学校级奖学金(五次),哈尔滨医科大学干部单项奖学金(一次),哈尔滨医科大学联邦奖学金 (一次)。
研究生期间:哈尔滨医科大学校级奖学金(三次)
已发表论文:
William Lee, Zishan Wang, Miriam Saffern, Tomi Jun, Kuan-lin Huang*.Genomic and molecular features distinguish young adult cancer from later-onset cancer. Cell reports 37, 110005, November 16, 2021.
Zishan Wang, Xiao Fan, Yufeng Shen, Meghana S Pagadala, Rebecca Signer, Kamil J. Cygan, William G. Fairbrother, Hannah Carter, Wendy K. Chung*, Kuan-lin Huang*. Non-cancer-related pathogenic germline variants and expression consequences in ten-thousand cancer genomes. Genome Medicine 13, 147 (2021).
Zishan Wang#, Jiaqi Yin#, Weiwei Zhou#, Jing Bai#, Yunjin Xie, Kang Xu, Xiangyi Zheng, Jun Xiao, Li Zhou, Xiaolin Qi, Yongsheng Li*, Xia Li*, Juan Xu*. Complex impact of DNA methylation on transcriptional dysregulation across 22 human cancer types. Nucleic Acids Research 2020, Vol. 48, No. 5 2287-2302.
Yongsheng Li#, Lili Li#, Zishan Wang#, Tao Pan, Nidhi Sahni, Xiyun Jin, Guangjuan Wang, Junyi Li, Xiangyi Zheng, Yunpeng Zhang, Juan Xu, Song Yi*, Xia Li*. LncMAP: Pan-cancer atlas of long noncoding RNA-mediated transcriptional network perturbations. Nucleic Acids Research 46, 1113-1123 (2018).
Juan Xu#, Zishan Wang#, Shengli Li#, Juan Chen, Jinwen Zhang, Chunjie Jiang, Zheng Zhao, Jing Li, Yongsheng Li*, Xia Li*. Combinatorial epigenetic regulation of non-coding RNAs has profound effects on oncogenic pathways in breast cancer subtypes. Briefings in Bioinformatics 19, 52-64 (2016).
Yongsheng Li#, Zishan Wang#, Yuan Wang#, Zheng Zhao, Jinwen Zhang, Jianping Lu, Juan Xu*, Xia Li*. Identifcation and characterization of lncRNA mediated transcriptional dysregulation dictates lncRNA roles in glioblastoma. Oncotarget 7(2016).
Yongsheng Li, Xiyun Jin, Zishan Wang, Lili Li, Hong Chen, Xiaoyu Lin, Song Yi*, Yunpeng Zhang*, Juan Xu*. Systematic review of computational methods for identifying miRNA-mediated RNA-RNA crosstalk. Briefings in Bioinformatics (2017).
Juan Chen, Juan Xu, Yongsheng Li, Jinwen Zhang, Hong Chen, Jianping Lu, Zishan Wang, Xueying Zhao, Kang Xu, Yixue Li*, Xia Li*, Yan Zhang*. Competing endogenous RNA network analysis identifies critical genes among the different breast cancer subtypes. Oncotarget 8(2017).
Juan Xu, Yongsheng Li, Jianping Lu, Tao Pan, Na Ding, Zishan Wang, Tingting Shao, Jinwen Zhang, Lihua Wang*, Xia Li*. The mRNA related ceRNA-ceRNA landscape and significance across 20 major cancer types. Nucleic Acids Research 43, 8169-82 (2015).
Yongsheng Li, Juan Chen, Jinwen Zhang, Zishan Wang, Tingting Shao, Chunjie Jiang, Juan Xu*, Xia Li*. Construction and analysis of lncRNA-lncRNA synergistic networks to reveal clinically relevant lncRNAs in cancer. Oncotarget 6(2015).
Yongsheng Li, Hong Chen, Tao Pan, Chunjie Jiang, Zheng Zhao, Zishan Wang, Jinwen Zhang, Juan Xu*, Xia Li*. LncRNA ontology_ inferring lncRNA functions based on chromatin states and expression patterns. Oncotarget 6(2015).
Yongsheng Li, Tingting Shao, Chunjie Jiang, Jing Bai, Zishan Wang, Jinwen Zhang, Lili Zhang, Zheng Zhao, Juan Xu*, Xia Li*. Construction and analysis of dynamic transcription factor regulatory networks in the progression of glioma. Scientific Reports 5, 15953 (2015).
Zheng Zhao, Jing Bai, Aiwei Wu, Yuan Wang, Jinwen Zhang, Zishan Wang, Yongsheng Li, Juan Xu*, Xia Li*. Co-LncRNA: investigating the lncRNA combinatorial effects in GO annotations and KEGG pathways based on human RNA-Seq data. Database (Oxford) (2015).
Zheng Zhao, Yongsheng Li, Hong Chen, Jianping Lu, Peter M Thompson, Juan Chen, Zishan Wang, Juan Xu*, Chun Xu*, Xia Li*. PD_NGSAtlas: a reference database combining next-generation sequencing epigenomic and transcriptomic data for psychiatric disorders. BMC Medical Genomics 7, 71 (2014).
书籍章节:
Zishan Wang,Xiyun Jin,Lili Li,Tao Pan,Juan Xu*.Chapter(Methods for Identification of Protein-RNA Interaction) in Non-coding RNAs in Complex Diseases(Part of the Advances in Experimental Medicine and Biology book series)